Theodoret of Cyrus
After initially battling the commanders of Darius in the lands of Asia, Alexander subdued their authority. Later, when Darius confronted him with a large army in Cilicia, a new conflict ensued. Darius retreated, and following his victory over the vast forces, Alexander took Darius' daughters as captives. Subsequently, during his return journey from Egypt, he engaged in combat near Babylon, ultimately slaying Darius and dismantling the Persian empire. The Prophet declares that both of the ram's horns were shattered; this is reflective of the fact that the Persians were referred to as both Midian and Persian, stemming from their first monarch, Cyrus, who was Midian through his mother and Persian through his father.
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Since their founding king bore both names, the subjects likewise identified as both Midian and Persian due to their shared governance, and even non-Jewish historians referred to them as such. The Prophet remarked on the breaking of the ram's horns.