He intensifies the obligation to purity because it was hard to wean them from impurity. In paganism it was so common that it was not even counted as sin. The corruption of man's fallen nature has made man especially prone to sins of the flesh.
The pagans overflowed in fornication, and among them were the Thessalonians, perhaps more openly, if not more than others. Therefore the Apostle spoke more against it orally, and now in writing places instruction on this first and sanctifies it by the will of God.
St. Chrysostom says on this word: "Notice that he never hints so often at anything else as at this. Writing elsewhere, he commands: 'Have peace and holiness with all, without which no one will see the Lord' (Heb 12:14).
And to Timothy he said: 'Keep yourself pure' (1 Tim 5:22). We shall find this in many places, in the Epistle to the Romans and in all the other epistles. Truly this evil is destructive for all."
Oecumenius adds: "In every epistle he offers much discourse concerning chastity. For he knew that there is no passion more unbridled and harder to correct."
Holiness, αγιασμος, sometimes means the sanctifying action of God's grace in the mysteries (1 Pet 1:2). Sometimes it means the purifying action of grace, received by freedom, as moral sanctification, purification, and correction of the soul (1 Cor 1:30).
Sometimes it means the state of moral purity, the established disposition to live purely and blamelessly according to all God's commandments. "Be holy, for I am holy," the Lord requires (1 Pet 1:16).
In the present case, the Apostle clearly understands holiness in the last sense, and specifically in relation to the purity of soul and body from passionate lust. This is shown by the following words: "abstain from fornication," which, in the flow of speech, directly explain the word "holiness."
General moral purity may only be understood as implied in this text, on the ground that without it purity from passionate lust, or chastity, cannot be formed or stand in its full meaning and power.
"Abstain from fornication" explains holiness. "Having said that the will of God requires holiness, he then makes known what virtue he calls holiness" (Theodoret). In Greek, "abstain" means to hold oneself away from something and withdraw from it.
By fornication he means every kind of bodily impurity. "There are many forms of disorder, and the delights of passion are manifold and various. It is unbearable even to speak of them. He cuts them all off with one word: 'abstain from fornication'" (Chrysostom).