Cyrill of Alexandria
I am like the panther of Ephraim and the lion of the house of Judah. I will rise up, I will go, and I will seize, and it shall not be taken from me. I will depart and return to my dwelling until they are lost. The reason for the ineffectiveness of Ephraim's protectors is evident, as is the reason for His continued suffering: "I am,” He declares, “as the panther of Ephraim and as the lion of the house of Judah.” It is clear that if God has turned away, there is none to deliver, for “his high hand, who will turn it back?” as stated in Isaiah 14:27. The afflictions they experienced left them bereft of all comforts, vividly portrayed by comparing His fury to the fiercest creatures.
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The leopard, when it pounces on its prey, does so with such swiftness that the signs of its approach are nearly undetectable; likewise, the lion's roar is so fearsome and thunderous in the mountains that it instills terror in those who hear it, as it is written, “the lion has roared; who will not fear?” (Amos 3:8). The lion strikes with overwhelming force and dashes forth with relentless speed; if it captures anything, it is forever lost, and none can reclaim its catch. The leopard is swift and vanishes after seizing what it desires, while the lion is indomitable, brave, and unstoppable. He reinforces this point by declaring, “And I will rise up, and I will go, and I will seize, and it shall not be taken from me.” This illustrates the might of lions, and "I will rise and go" signifies the panther, which acts in a similarly swift manner.