The phrase "For they said that He was out of Himself" indicates two possible meanings: in a favorable sense, it can refer to being in a state of profound spiritual and moral zeal (as expressed in 2 Corinthians 5:13), and in a negative context, it implies a lack of soundness of mind (the Greek ἐξε'στη translates similarly to μαι'νεσυαι, reflecting why the Vulgate interprets it as furorem). More specifically, this reflects the Pharisees' claims that He was possessed by Beelzebub (Mark 3:22). Given the context, we should interpret "went out of Himself" in the latter, more critical sense. It is likely that the Lord’s adversaries propagated this narrative to tarnish His reputation among the people, aiming to diminish or eliminate His influence over the crowds—news of this reached Jesus’ neighbors in Nazareth, prompting them to intervene.
In this context, the phrase "they spoke" should be understood as impersonal; it was not the neighbors directly voicing these claims, but rather others circulating the rumor that eventually reached them, leading to their decision to act. If we assume that "they said" refers to the neighbors themselves, it raises the question of whether they truly meant to affirm that "He went out of Himself" in the positive sense noted earlier. Notably, the Gospel of John states (John 7:5) that “even His brethren did not believe in Him” as the Messiah, at least for some time. They may have struggled with their perception of His humble circumstances, perhaps influenced by the prevailing misconception that the Messiah would appear in regal grandeur.
Having lived alongside them as the son of a carpenter until the age of thirty, Jesus then embarked on a ministry characterized by extraordinary acts. Could they have been swayed by this radical shift, leading them to suspect that, despite His extraordinary miracles, He was indeed out of His mind? Nonetheless, if the Lord's siblings harbored such thoughts, His mother—who understood the mystery surrounding her Son—could not share in their doubts. It was likely her maternal instinct, rather than any such misgivings, that compelled her to seek Him out, possibly worried by the rumor that He had lost His composure and might find Himself in jeopardy from His adversaries.