John Chrysostom
After addressing the adversities that would confront the city, as well as the trials faced by the apostles who would emerge triumphant and spread their message throughout the world, the Savior speaks once more about the tribulations of the Jewish people. He indicates that when the apostles, after proclaiming the Gospel to the entire world, receive their honor, the Jewish people will endure great suffering. Notice how He discusses warfare, conveying its brutality with seemingly trivial words. "Then," He states, "let those who are in Judea flee to the mountains." "Then" refers to what moment? "When all these things shall come to pass, when you see the abomination of desolation in the holy place." From this, I deduce that He is referring to the invading armies.
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He instructs them to flee, indicating that their chances for salvation have vanished. Historically, during times of intense conflict, the Jewish people have often found renewed strength, such as in the days of Sennacherib and Antiochus, when, despite the siege on the city and the temple's capture, the Maccabees rallied against their foes and turned the tide. Therefore, to prevent them from harboring any such expectations for a turnaround in their fate, He strips away all hope.