Andrew of Caesarea
According to some, the four angels are Michael, Gabriel, Uriel, and Raphael. They are bound by the joy of contemplation of the Godhead and are loosed with the other angels on the day of judgment for the condemnation of the impious, a third of whom will be destroyed.
But I think these are evil demons, bound at the coming of Christ. Now, by the command of God proceeding from the altar above the heavens, whose image was in the tabernacle of Moses, they are loosed by the divine angel.
They are loosed to stir up the nations, not only against the faithful, but also against one another. Through this, some may prove faithful, tested, and worthy of the higher reward.
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Like ripe wheat, they will be worthy of the heavenly dwellings and granaries. Others, the impious and unrepentant sinners, will be justly punished here and will receive an even harsher condemnation at the dread judgment, as worthless tares.
They were bound at the Euphrates. There is nothing strange in this, for by God's will some were condemned for a time to the abyss, others to the swine, and others to other places.
This was so that, after the complete end of their warfare against men, they might undergo eternal torments. It may also be that the mention of the Euphrates indicates that the antichrist will come from those regions.