This is how Saint Chrysostom, Theophylact, Theodoret, and Ambrose interpret it. This interpretation of the Fathers of the Church is fully justified by the further course of the apostolic discourse. In answer to the Apostle's prayer that the Lord would remove the angel of Satan from him and end his afflictions, the Lord answered: "My grace is sufficient for you, for My power is made perfect in weakness."
After this the Apostle observes: "Therefore I take pleasure in weaknesses, in reproaches, in necessities, in persecutions, in distresses for Christ. For when I am weak, then I am strong" (2 Cor 12:10). Here there is a direct explanation of the Apostle's preceding words about the afflicter and the afflictions of the angel of Satan.
That the afflictions done to Saint Paul by the angel of Satan were not, as some think, sensual flare-ups arising from diabolical incitement, is clear from the following.
First, what is rendered in the Slavonic text as "afflicter of the flesh" is designated in the Greek original by the word for a point or a piercing stake, σκόλοψ τῆ σαρκί. This gives the idea of sharp pain or a burning prick. This plainly does not accord with the softness and sweetness of fleshly passion.
Second, the words of the Greek original concerning the devil, rendered in Slavonic as "that he might afflict me," properly mean "that he might strike me on the cheeks, give me blows on the face," ϊνα με κολαφίζη. This expresses crude disgrace and open humiliation. Yet we know that in fleshly lust the enemy acts in the most flattering, insinuating, and caressing manner.
Third, from the course of the apostolic discourse one may note that the Apostle wishes to speak of some particular method devised and used by the devil specifically against him, to hinder him in his apostolic activity.
What is particular about fleshly passion? It is not alien to anyone conceived in iniquity and born in sins. True, it can greatly humble those who are zealous for piety, and the Apostle does say, "lest I be exalted." Yet the devil did not wish to teach humility, but only to hinder and obstruct the Apostle. The Apostle humbled himself.
Why, then, should the greatest hindrance to apostolic activity be seen only in fleshly passion? There are no grounds for this.
Fourth, the Apostle's statement that he prayed three times to the Lord that the devil and his afflictions might depart from him would be perplexing if his prayer were directed specifically against desires of the flesh. One must pray not three times, but continually, for victory over the desires of the flesh.
One must pray not three times, but continually, for victory over this inward enemy of ours, which does not die until our own death. Clearly the afflictions done to the Apostle came from without and fought against him independently of the natural inclinations of fallen human nature.
On the basis of the considerations noted above, some interpreters understand the satanic afflictions as bodily ailments. They ascribe to the Apostle various illnesses that oppressed and humiliated him, such as epilepsy, gastric disorder, severe headache, disease of the eyes or ears, rheumatism, and the like.
Yet the devil could hardly have had such power over the body of Saint Paul as to send illnesses upon him. It is known that the devil himself obeyed the Apostle of Christ and trembled at his authority (1 Cor 5:4-5; Acts 16:8-19:13).