Jerome of Stridon
Then I beheld another beast resembling a leopard, adorned with four wings of birds, and possessing four heads. Authority was granted to him. The third kingdom, the Macedonian realm noted in the vision of the statue—its belly and thighs made of brass (Dan. 2:32)—is likened to the leopard, the quickest of beasts known for its relentless pursuit of bloodshed and its swift leaps to enact death. He had four wings, as nothing was swifter than the triumphs of Alexander, who, from Illyria and the Adriatic Sea to the Indian Ocean and the River Ganges, moved rapidly—not merely among conflicts but amid victories. In just six years, he conquered parts of Europe and all of Asia. The four heads represent the leaders who later succeeded him in governance: Ptolemy, Seleucus, Philip, and Antigonus. The phrase "and authority was given to him" indicates that these achievements stemmed not from Alexander’s own bravado, but from the divine decree of the Lord.