Jerome of Stridon
I observed the horns and noticed that from their midst emerged another small horn, which caused three of the initial horns to be uprooted. This horn had eyes resembling those of men and a mouth that spoke with great arrogance. Porphyry incorrectly suggests that this little horn refers to Antiochus Epiphanes, associating the three expelled horns with the sixth king, Ptolemy Philometor, the seventh, Ptolemy Euergetes, and Artarxias, the king of the Armenians. It should be pointed out that the first of these kings passed away long before the birth of Antiochus, and Artarxias retained his kingdom, even though, as is known, Antiochus engaged in conflict with him.
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Thus, we must affirm what has been expressed by many ecclesiastical writers: at the end of days, when the Roman Empire is dismantled, there will be ten kings who will partition the Roman world among themselves. An eleventh king, a lesser one, will rise to power and defeat three of these ten, specifically the rulers of Egypt, Africa, and Ethiopia, which we will elaborate upon later. Following their overthrow, the remaining seven kings will also fall under the authority of this victor. And it is stated, this horn possessed eyes like those of men. Therefore, we must not view him, as some have posited, as a demon or an evil spirit, but rather as a mere man in whom all of Satan will take residence bodily. The mouth that speaks with arrogance represents the man of sin, the son of perdition, who audaciously sits in the temple of God, claiming to be the Son of God (2 Thess. 2).