Ephraem the Syrian
Upon departing from Midian, God instructs him to declare to Pharaoh, "Let my firstborn son go so that he may worship Me. If you refuse to let him go, I will take your firstborn son." Before unleashing the plagues, God warns Pharaoh of this dire consequence: the death of his firstborn, which stands as the most severe of all the afflictions. Yet, in reality, He demonstrates the smallest of all the signs—the sign of the serpent.