The Old Testament high priest felt himself guilty before God and therefore offered a propitiatory sacrifice. Christ felt Himself only weak, subject to temptations and fearful before evil.
Therefore He was content to offer to God, as sacrifice, tearful prayers. These prayers blotted out before the face of God this weakness, namely, fear before evil.
The Apostle, however, does not use the expression "God" in the latter case. He replaces this word with the descriptive expression, "the One able to save His soul from death."
He probably does this in order to indicate the danger from which Jesus prayed to be delivered. But what moment from the life of Jesus Christ does the Apostle mean when he speaks of loud cries and tears with which He prayed to God?
Most probably he means the sufferings of Jesus Christ in Gethsemane. Although the Gospels say nothing about Christ's cries during the prayer in Gethsemane, such cries could very easily have taken place.
For Christ was in a state of special inward tension, αγωνία (Lk 22:41-43). But Christ prayed in Gethsemane for deliverance from death. How, then, does the Apostle say that He was heard by God?
No. If Christ had prayed only for this, His prayer not only would have remained unheard, but would have contradicted all His previous proofs of the necessity of this death.
This is all the more so since Christ knew well that He would rise on the third day. What was truly grievous for Christ was to drink the cup of sufferings appointed for Him.
These sufferings did not consist only in His being handed over to torment in the hands of sinners. That would not have been so terrible, since Christ certainly was not weaker than many martyrs who joyfully accepted torments for the faith.
No. Christ had to take upon Himself responsibility for the sins of all mankind and to give His soul as redemption for the sins of the whole world.
This compelled Him to enter into battle with the devil, the prince of this world. This struggle terrified His human nature and compelled Him to turn to God the Father with anxious cries.
He prayed that the Father would help Him in this struggle and would not leave His soul in the power of death and the devil. And such a prayer was heard by God.
After the inward struggle in Gethsemane, Christ calmly went to death. If once more the weakness of the flesh declared itself on the Cross in the cry, "My God, My God, why hast Thou forsaken Me?" He nevertheless soon could commit His soul into the hands of God with a joyful cry.
Then the Apostle says that Christ was heard because of His reverent fear, άπα τής εύλαβείας. This means that the previously mentioned prayers of Christ were called forth by His reverence and were an outward proof of it.