Cyrill of Alexandria
The blessed prophet Isaiah delivered his messages during the reigns of Hosea, Jehoiakim, Ahaz, and Hezekiah. It appears that he spoke this specific prophecy against Babylon, or concerning the entire region of Assyria, while Uzziah, also known as Azariah, still held the throne. During Hezekiah's rule, the Assyrian king Sennacherib waged war against Judah, capturing numerous cities in Samaria. When he attacked Jerusalem, the Lord shamed him, for in a single night, the angel of the Lord struck down one hundred and eighty-five thousand warriors. To ensure that the promises made by God for the comfort of Israel would not go unfulfilled, He proclaims these truths, asserting that what He has decreed will indeed come to pass.
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Babylon shall be transformed into a desolate wasteland, and it will remain so indefinitely. He declares that all He has determined, confirmed through His judgment to annihilate the Assyrians in His land and in His mountains, will be accomplished; they will be trodden down, their possessions will be taken away, and their glory will vanish.
Sennacherib sent his envoy Rabshekah from Lachish to Jerusalem. Surrounding the city with Assyrian forces, Rabshekah blasphemed the glory of God and spoke with a savage disdain, declaring, "Let not Hezekiah deceive you, saying, 'Your God will surely deliver you from the hand of the Assyrians'" (Isaiah 36:18). However, when he attempted to impose bondage upon those who were originally free, claiming for himself and his master an unfounded glory, he faced unforeseen disaster. For upon rising early in the morning, he discovered all the bodies lifeless (2 Kings 19:35). He learned firsthand that the Leader of the faithful is all-powerful, and that nothing can stand against His divine will.