Cyrill of Alexandria
Loosen your grip on your understanding, be filled with dread, and become intoxicated, not by strong drink or wine. For the Lord will instill in you a spirit of penitence and will extinguish the insight of their eyes, as well as that of their prophets and leaders, leaving them blind to hidden truths. This message is directed toward those who have scorned divine evidence and sought to trivialize the sacred and heavenly truths of the gospel. Although they had the opportunity and it would have been quite beneficial for them to receive the grace of redemption through Christ by humbly submitting their minds, they neglected to do so. Instead, they were consumed with pride, claiming, “We are disciples of Moses. We know that God spoke to Moses, but we do not know this man” (John 9:28, 29).
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Yet they heard Christ clearly proclaim, "I am the light of the world" (John 8:12), and were urged to walk in that light so that darkness would not overtake them (John 12:35). When confronted with these sacred words, rather than growing wiser or more virtuous, they became increasingly hard-hearted and rebellious. Consequently, they fell deeper into darkness and, in an uncharacteristic indulgence, lost all sense of prudence, swaying into shameful acts as if overcome by wine. In this context, it is said to them, “Be at ease and be agitated, be intoxicated, but not with sweet syrup or wine. It is not mere wine or a fermented beverage that clouds the mind, but rather the distressing effects of affliction and the numbing that stems from divine displeasure.” This, I believe, is reflected in the statement, "And thou shalt shut their eyes, as well as the eyes of their prophets and princes, to the things that are hidden." He refers to those in ancient times, wise in the law, who grasped the beauty of truth but only in shadowy glimpses, and who partially understood the messages of the holy prophets. They will be stripped of this wisdom; God will blind their understanding, which once perceived those hidden truths. This fate will befall both the ruler and the priest. The term 'prophets' was attributed to those dedicated to the study of the sacred teachings; among the Jews, figures like Gamaliel held such esteemed knowledge of the laws and were well-regarded as teachers.