Jerome of Stridon
When He declares that due to the abominations of the people He will hide His face from them and deem them unworthy of His gaze, they will consequently desecrate His innermost sanctuary, which refers to the Holy of Holies. The Septuagint translates this as the place of visitation to signify that this sacred area was intended to be where God’s presence was revealed. The vile and destructive forces of the earth will encroach upon it, a place where only the priests and high priest were permitted to enter. This was historically fulfilled by the Babylonians, King Antiochus, Gnaeus Pompey, and ultimately under Vespasian and Titus, when the temple was captured and devastated, leading to the fulfillment of all that the prophet spoke of thereafter.
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Similarly, because of our transgressions, God averted His gaze, which results in the profanation of His sacred truths. This leads to a situation where, rather than being populated by priests and saints, what ought to have been a sanctuary devolves into a source of impurity. As the Gospel declares: 'My Father's house shall be called a house of prayer, but you have made it a den of robbers' (Matthew 21:13; John 2:17).