Theophylact of Bulgaria
It was also His custom always to pray by Himself, in order to give us an example, to seek for silence and solitude in our prayers. There follows: And he taketh with him Peter, and James, and John. He takes only those who had been witnesses of His glory on Mount Tabor, that they who had seen His glory might also see His sufferings, and learn that He is really man, in that He is sorrowful. Wherefore there follows: And began to be sore amazed, and very heavy. For since He had taken on Himself the whole of human nature, He took also those natural things which belong to man, amazement, heaviness, and sorrow; for men are naturally unwilling to die. Wherefore it goes on: And he saith unto them, My soul is exceeding sorrowful unto death.
But some have understood this, as if He had said, I am sorrowful, not because I am to die, but because the Jews, my countrymen, are about to crucify me, and by these means to be shut out from the kingdom of God.
As if He had said, Your spirit indeed is ready not to deny me, and for this reason ye promise; but your flesh is weak, in that unless God give power to your flesh through prayer, ye shall enter into temptation.
That by His second prayer He might shew Himself to be very man. It goes on: And when he returned, he found them asleep again; He however did not rebuke them severely. For their eyes were heavy, (that is, with sleep,) neither wist they what to answer him. By this learn the weakness of men, and let us not, whom even sleep can overcome, promise things which are impossible to us. Therefore He goes away the third time to pray the prayer mentioned above. Wherefore it goes on: And he cometh the third time, and saith unto them, Sleep on now, and take your rest. He is not vehement against them, though after His rebuke they had done worse, but He tells them ironically, Sleep on now, and take your rest, because He knew that the betrayer was now close at hand.
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And that He spoke ironically is evident, by what is added: It is enough, the hour is come; behold, the Son of man is betrayed into the hands of sinners. He speaks this, as deriding their sleep, as if He had said; Now indeed is a time for sleep, when the traitor is approaching. Then He says; Arise, let us go; lo, he that betrayeth me is at hand; he did not say this to bid them fly, but that they might meet their enemies.