Cyrill of Alexandria
If anyone seeks to cleanse himself before God following the noble commitment to embody the highest form of life and to tread the pure and direct path of complete truth, he must distance himself from wine and intoxicating beverages, liberating his spirit from all that can cloud and confuse it. This includes, in my view, worldly distractions, earthly desires, fleshly concerns, and vanity. The prophetic voice laments concerning certain priests, stating, "The priest and the prophet stagger from wine; they are entangled by strong drink" (Isaiah 28:7).
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Additionally, the prophet declares about others, "For their vine is from the vine of Sodom, and from the fields of Gomorrah; their grapes are poisonous; their clusters are bitter; their wine is the venom of serpents and the cruel poison of asps" (Deuteronomy 32:32-33). Furthermore, it is said of some, "Woe to him who gives drink to his neighbor, pouring out your wrath and making him drunk" (Hab. 2:15). Thus, the law safeguards the minds of the sanctified from any potential intoxication. It clearly states that they must not even touch vinegar, referring to it, as I believe, as a symbol of unnatural and distorted pleasures. The use of raisins and grains is likewise prohibited, ensuring that our thoughts do not stray, even subtly, to remnants of our natural inclinations toward enjoyment. For these reasons, as I understand, the law excludes wine and all its derivatives.