Indeed the Apostle says: "Your boasting is not good. Do you not know that a little leaven corrupts the whole lump?" (1 Cor 5:5-6). Or, as we have already rendered it: "A little leaven leavens the whole dough." Immediately afterward he adds: "Cleanse out the old leaven, that you may be a new lump, as you are unleavened. For Christ our Passover has been sacrificed. Therefore let us keep the feast, not with the old leaven, nor with the leaven of malice and wickedness, but with the unleavened bread of sincerity and truth" (1 Cor 5:7-8).
Now by the same instruction he teaches that the spiritual Bread of the Church, Who comes down from heaven, must not suffer violence from a Jewish interpretation. The Lord gave the same command to His disciples, namely, that they should beware of the leaven of the Pharisees (Jn 6). The Evangelist makes this clearer by adding: "He spoke to them of the teaching of the Pharisees" (Mt 16:12).
What other teaching of the Pharisees is meant, if not the observance of the Law according to the flesh? Thus the meaning is this. Do not think that the snares of those few men, who come from Judea and teach otherwise, should be treated with contempt.
A spark is something small, and is hardly even seen while it appears. Yet if fire, however small, falls upon a hearth and finds food for itself, it destroys walls, cities, and vast forests, and lays waste whole lands.
So too leaven, presented in another sense in the parable (Lk 13:20-21), seems a small and even insignificant thing. Yet when, joined with flour, it leavens the whole lump by its sourness, the entire mixture yields to its power.
In the same way perverse teaching begins with one man and at first finds barely one or two hearers. Little by little it spreads like cancer in the body. As the popular saying has it, one diseased animal infects the whole flock.
Therefore the spark must be quenched as soon as it appears. The leaven must be removed from the dough. The infected piece must be cut away from the flesh. The diseased animal must be driven from the flock of sheep.
Otherwise the whole house will burn, the dough will sour, the body will rot, and the flock will perish. Arius in Alexandria was one spark. Since he was not quenched at once, the flame from him seized the whole world.